CURRENT Lab Members

image16

Ian Gibbs-Seymour, Principal Investigator

Research background:

2011-2014 - Postdoctoral researcher (University of Copenhagen)

2014-2017 - Postdoctoral researcher (University of Oxford)


After completing my doctoral research in Durham, I joined the group of Niels Mailand in the Center for Protein Research, University Copenhagen. After three years, I returned to the UK to work with Ivan Ahel in the Sir William Dunn School of Pathology, with the support of a Marie Skłodowska-Curie Fellowship and a Nicholas Kurti Junior Research Fellowship, Brasenose College, University of Oxford.  
 

During my postdoctoral research I focussed on investigating how post-translational modifications (PTMs) regulate and impact DNA repair in mammalian cells. 


Now, with the support of a CRUK Career Development Fellowship, I will investigate how PTM signalling controls replication-coupled DNA repair.

image17

Ben Foster, Postdoctoral Researcher

Research background:

2012-2013 - Masters/Part III student (University of Cambridge)

2013-2017 - PhD student (Imperial College London/MRC LMS)

2017-2018 - Postdoctoral researcher (Helmholtz Zentrum München)


Ben carried out his Bachelor and Masters studies in Natural Sciences at the University of Cambridge, with his Part III project concerning the function of a ubiquitin-like modifier (Urm1) in Archaea. He moved to the MRC London Institute of Medical Sciences in 2013 to start his doctoral research with Till Bartke before moving to Munich with Till for a short Post-doc in the Institute of Functional Epigenetics (IFE) at the Helmholtz Zentrum München. During his PhD/Post-doc with Till, Ben was involved in investigating how modifications on histones and DNA are written and read by chromatin reader proteins, with particular attention on how UHRF1 ubiquitylates histone H3 in its role for maintaining DNA methylation after replication.


Now, Ben is will investigate the biochemical activity and function of proteins involved in the PTM-signalling associated with replication-coupled DNA repair.


image18

George Dobson, DPhil candidate

Research background:


2018-present - DPhil BBSRC Interdisciplinary Bioscience (Linacre College, University of Oxford)

2013-2018 - MBiol (Durham University )


George completed an integrated Masters course in Bioscience at Durham University. During his final year project in Martin Cann’s group, George investigated a potential new post-translational modification of ubiquitin, and how this impacted the formation of polyubiquitin chains. George has also undertaken summer projects at King’s College London and the Chinese Academy of Science Institute of Biophysics, Beijing. 


As part of a 12-week rotational project, George will investigate ZUP1 function using biochemical approaches.

PAST LAB MEMBERS

image19

Matt Drake, DPhil candidate, 2019

Research background:

2018-present - DPhil BBSRC Interdisciplinary Bioscience (Merton College, University of Oxford)

2017-2018 - MSc Drug Discovery (King’s College London/ AstraZeneca)

2013-2017 - BSc (Hons) Biochemistry (University of Edinburgh)


Matt carried out a BSc (Hons) degree in Biochemistry at The University of Edinburgh before moving on to an MSc degree in Drug Discovery at King’s College London with an industrial placement at AstraZeneca in Cambridge. His research focused on developing a cell-based split protein luminescence assay to quantify the induced degradation of cancer related proteins by novel proteolysis targeting chimera (PROTAC) molecules. 


As part of a 12-week rotational project Matt helped us get started with our genome-wide CRISPR/Cas9 screening approaches.

image20

Phoebe Hobbs, MBiochem candidate (Part II Project), 2018-2019

Research background:

As well as her Biochemistry undergraduate practical classes, Phoebe carried out a summer project at UCL  and was keen to pursue cell biology methodologies in the lab.


During the 18-week Part II project, Phoebe worked on aspects of how mammalian cells use single-stranded DNA as a platform for protein signalling.