CURRENT Lab Members

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Ian Gibbs-Seymour, Principal Investigator

Research background:

2011-2014 - Postdoctoral researcher (University of Copenhagen)

2014-2017 - Postdoctoral researcher (University of Oxford)


After completing my doctoral research in Durham, I joined the group of Niels Mailand in the Center for Protein Research, University Copenhagen. After three years, I returned to the UK to work with Ivan Ahel in the Sir William Dunn School of Pathology, with the support of a Marie Skłodowska-Curie Fellowship and a Nicholas Kurti Junior Research Fellowship, Brasenose College, University of Oxford.  
 

During my postdoctoral research I focussed on investigating how post-translational modifications (PTMs) regulate and impact DNA repair in mammalian cells. 


Now, with the support of a CRUK Career Development Fellowship, I will investigate how PTM signalling controls replication-coupled DNA repair.

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Ben Foster, Postdoctoral Researcher

Research background:

2012-2013 - Masters/Part III (University of Cambridge)

2013-2017 - PhD (Imperial College London/MRC LMS)

2017-2018 - Postdoctoral researcher (Helmholtz Zentrum München)


Ben carried out his Bachelor and Masters studies in Natural Sciences at the University of Cambridge, with his Part III project concerning the function of a ubiquitin-like modifier (Urm1) in Archaea. He moved to the MRC London Institute of Medical Sciences in 2013 to start his doctoral research with Till Bartke before moving to Munich with Till for a short Post-doc in the Institute of Functional Epigenetics (IFE) at the Helmholtz Zentrum München. During his PhD/Post-doc with Till, Ben was involved in investigating how modifications on histones and DNA are written and read by chromatin reader proteins, with particular attention on how UHRF1 ubiquitylates histone H3 in its role for maintaining DNA methylation after replication.


Now, Ben is will investigate the biochemical activity and function of proteins involved in the PTM-signalling associated with replication-coupled DNA repair.


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Martin Attwood, Postdoctoral Researcher

Research background:

2010-2011 - MSc (University College London)

2013-2017 - DPhil (University of Oxford)

2018-2019 - Postdoctoral researcher (University College London)


Martin completed his DPhil in Clinical Medicine from the University of Oxford in 2017 where he worked under the guidance of Professor Peter Ratcliffe to characterise the cellular role of a ribosomal hydroxylase enzyme within the 2-oxoglutarate oxygenase superfamily. Martin then joined the lab of Professor Hart in 2018 at University College London to investigate gene editing approaches for the treatment of Cystic Fibrosis. His research explored the use of receptor-targeted nanoparticles as a delivery route to enhance gene editing efficiency.  


Martin is now investigating the cellular functions of proteins that are responsible for regulating PTMs involved in the DNA damage response.  

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Matt Drake, DPhil candidate

Research background:

2013-2017 - BSc (Hons) Biochemistry (University of Edinburgh)

2017-2018 - MSc Drug Discovery (King’s College London/AstraZeneca)

2018-present - DPhil BBSRC Interdisciplinary Bioscience (Merton College, University of Oxford)


Matt carried out a BSc (Hons) degree in Biochemistry at The University of Edinburgh before moving on to an MSc degree in Drug Discovery at King’s College London with an industrial placement at AstraZeneca in Cambridge. His research focused on developing a cell-based split protein luminescence assay to quantify the induced degradation of cancer related proteins by novel proteolysis targeting chimera (PROTAC) molecules. 


After an initial 12-week rotation project, Matt re-joined the lab to get trained in various cell biology approaches, including CRISPR/Cas9 screening.

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Kay Chong, DPhil candidate

Research background:


2013-2016 - BSc (Hons) Biomedical Science (Imperial College London)

2017-2018 – Research Assistant (Yale University)

2020-present - DPhil in Biochemistry (Trinity College, University of Oxford)


Kay carried out her BSc degree at Imperial College London, after which she worked as Research Assistant at Yale University in the lab of Professor Yang Yang-Hartwich. Her research focused on the regulation of TWIST1 transcription by heat shock protein 90 and how this promotes epithelial-mesenchymal transition in cancer cells.


Kay is now investigating the cellular roles of proteins involved in DNA repair pathways that are defective in cancers such as ovarian cancer.

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Kay Chong, DPhil candidate

Research background:


2013-2016 - BSc (Hons) Biomedical Science (Imperial College London)

2017-2018 - Research Assistant (Yale University)

2020-present - DPhil in Biochemistry (Trinity College, University of Oxford)


Kay carried out her BSc degree at Imperial College London, after which she worked as Research Assistant at Yale University in the lab of Professor Yang Yang-Hartwich. Her research focused on the regulation of TWIST1 transcription by heat shock protein 90 and how this promotes epithelial-mesenchymal transition in cancer cells.


Kay is now investigating the cellular roles of proteins involved in DNA repair pathways that are defective in cancers such as ovarian cancer.

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Ryan Gilroy, MBiochem candidate (Part II Project), 2019-2020

Research background:
2016-present - MBiochem Biochemistry (Molecular and Cellular) (Wadham College, University of Oxford)


Ryan is carrying out his Part II research project in the lab and is using biochemical approaches to understand how enzymes involved in DNA repair are able to choose their substrates.

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Kira Schuetzenhofer, MSc by Research Candidate

Research background:
2016-2019 - BSc (Hons) Human Sciences (University College London)
2019 - present - MSc by Research in Biochemistry (Corpus Christi College, University of Oxford)


After completing her BSc, Kira joined the lab to investigate the role of PTMs in the regulation of proteins involved in the DNA damage response using a variety of cell biology approaches.

PAST LAB MEMBERS

Phoebe Hobbs, MBiochem candidate (Part II Project), 2018-2019

During the 18-week Part II project, Phoebe worked on aspects of how mammalian cells use single-stranded DNA as a platform for protein signalling.

George Dobson, DTP DPhil candidate , 2019


As part of a 12-week rotation project, George investigated the function of DNA repair proteins using biochemical approaches.